Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 7

• Cat.No.: PAK7-522H
• Product Overview: Recombinant Human PAK7 (amino acids 425-719) was expressed inE.coli.MW=33.9 kDa.

Specification

• Cat. No.: PAK7-522H
• Description: PAK7 (also known as PAK5) is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.
• Source: E.Coli.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 5 mM DTT.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at -80°C.

Gene Information

• Gene Name: PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 [ Homo sapiens ]
• Synonyms: PAK7; p21 protein (Cdc42/Rac)-activated kinase 7; PAK5; KIAA1264; MGC26232; OTTHUMP00000030260; p21(CDKN1A)-activated kinase 7; p21-activated kinase 7; p21CDKN1A-activated kinase 7; protein kinase PAK5; serine/threonine-protein kinase PAK7; EC 2.7.11.1
• Gene ID: 57144
• mRNA Refseq: NM_020341
• Protein Refseq: NP_065074
• MIM: 608038
• UniProt ID: Q9P286
• Chromosome Location: 20p12
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity