||Recombinant Human PAK7 (amino acids 425-719) was expressed inE.coli.MW=33.9 kDa.
||PAK7 (also known as PAK5) is a novel human PAK family kinase that contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. The p21-activated kinase (PAK) family of protein kinases has recently attracted considerable attention as an effector of Rho family of small G proteins and as an upstream regulator of MAPK signalling pathways during cellular events such as re-arrangement of the cytoskeleton and apoptosis. PAK7 like the other Paks has been implicated in the regulation of cell morphology, motility and transformation.
||25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, and 5 mM DTT.
||Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
||>6 months at -80°C.