"PTPN14" Related Products

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Recombinant Human PTPN14, GST-tagged

Cat. No. : PTPN14-454H
Product Overview : Recombinant Human Catalytic domain, (a.a. 817-1188), with N-terminal GST tag expressed in anE.coliexpression system. MW= 61 kDa.
Description : Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.
Source : E.Coli.
Purity : >90% by SDS-PAGE.
Application : Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Stability : >12 months at –80°C.
PDB rendering based on 2bzl. :

Gene Name : PTPN14 protein tyrosine phosphatase, non-receptor type 14 [ Homo sapiens ]
Synonyms : PTPN14; protein tyrosine phosphatase, non-receptor type 14; PEZ; PTP36; MGC126803; cytoskeletal-associated protein tyrosine phosphatase; EC 3.1.3.48; Tyrosine-protein phosphatase non-receptor type 14; Protein-tyrosine phosphatase pez
Gene ID : 5784
mRNA Refseq : NM_005401
Protein Refseq : NP_005392
MIM : 603155
UniProt ID : Q15678
Chromosome Location : 1q32.2
Function : binding; hydrolase activity; protein tyrosine phosphatase activity

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