Native Human VTN

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Native Human VTN

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Cat.No. : VTN-31736TH
Product Overview : Full length Vitronectin purified from Human plasma, MWt 75 kDa.
Description : The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
Tissue specificity : Plasma.
Biological activity : Second order rate constants for inhibition of:uPA = 6.3 x 106 M-1s-1tPA = 5.7 x 106 M-1s-1
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Sodium phosphate, 100mM Sodium chloride, pH 7.4
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain.
Gene Name : VTN vitronectin [ Homo sapiens ]
Official Symbol : VTN
Synonyms : VTN; vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S protein); complement S protein; serum spreading factor; somatomedin B; VN;
Gene ID : 7448
mRNA Refseq : NM_000638
Protein Refseq : NP_000629
MIM : 193190
Uniprot ID : P04004
Chromosome Location : 17q11.2
Pathway : ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; FOXA1 transcription factor network, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem;
Function : extracellular matrix binding; heparin binding; integrin binding; polysaccharide binding; scavenger receptor activity;

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