Recombinant Mouse Tnfrsf10b

• Cat.No.: Tnfrsf10b-178M

Specification

• Cat. No.: Tnfrsf10b-178M
• Description: Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells. TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients.
• Source: Sf 21 Insect Cells.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse TRAIL R2 is Mr 40 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 49 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b [ Mus musculus ]
• Synonyms: Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
• Gene ID: 21933
• mRNA Refseq: NM_009379
• Protein Refseq: NP_033405
• UniProt ID: P40226
• Chromosome Location: 14 D2
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction; Natural killer cell mediated cytotoxicity
• Function: TRAIL binding; caspase activator activity; protein binding; receptor activity