"EPHB2" Related Products


Recombinant Human EPH Receptor B2, His-tagged

Cat. No.: EPHB2-542H
Product Overview: Recombinant human EPHB2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=52kDa.
Description: EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neurodevelopmental processes such as boundary formation, axon guidance, vasculogenesis, and cell migration. EPHB2 has been shown to associate with the non-receptor tyrosine kinase Abl and activated EPHB2 causes tyrosine phosphorylation of Abl and regulates its activity. EPHB2 is overexressed in a number of tumors particularly glioblastoma and this increases glioma cell migration and invasion.
Source: Sf9 insect cells.
Purity: >80%.
Specific Activity: 21.8 pmol/min/μg. Enzyme reaction is conducted in a buffer containing 50 mM HEPES (pH7.5), 10 Mm MgCl2, 1 mM EGTA, 200 μM ATP, 0.01% Brij-35 and 2 μM substrate (Invitrogen ZLyte Peptide 1) at room temperature for 1 hour.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT.
Stability: >12 months at –80°C.
Gene Name: EPHB2 EPH receptor B2 [ Homo sapiens ]
Synonyms: EPHB2; EPH receptor B2; DRT; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492; EphB2; eph tyrosine kinase 3; ephrin type-B receptor 2; elk-related tyrosine kinase; protein-tyrosine kinase HEK5; EC; EPTH3; TYRO5; OTTHUMP00000002914; OTTHUMP00000002916; Receptor protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3; developmentally-regulated eph-related tyrosine kinase; eph tyrosine kinase 3; ephrin receptor EphB2
Gene ID: 2048
mRNA Refseq: NM_004442
Protein Refseq: NP_004433
MIM: 600997
UniProt ID: P29323
Chromosome Location: 1p36.1-p35
Pathway: Axon guidance
Function: ATP binding; axon guidance receptor activity; nucleotide binding; receptor activity; receptor binding; transferase activity; transmembrane-ephrin receptor activity

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