Recombinant Mouse Platelet Factor 4

• Cat.No.: Pf4-152M
• Product Overview: Recombinant Mouse CXCL4 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 73 amino acids and having a molecular mass of 8.2 kDa.

Specification

• Cat. No.: Pf4-152M
• Description: Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
• Source: Escherichia Coli.
• Amino Acid Sequence: MGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES.
• Physical Appearance: Sterile Filtered white lyophilized powder.
• Formulation: The Mouse CXCL4 protein was lyophilized from 1x PBS pH-7.4.
• Stability: Mouse CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: Pf4 platelet factor 4 [ Mus musculus ]
• Synonyms: Pf4; platelet factor 4; Cxcl4; Scyb4; PF-4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
• Gene ID: 56744
• mRNA Refseq: NM_019932
• Protein Refseq: NP_064316
• UniProt ID: Q9Z126
• Chromosome Location: 5 E1
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity; cytokine activity; heparin binding