Recombinant Human Arachidonate 15-lipoxygenase, Type B, His-tagged

• Cat.No.: ALOX15B-580H
• Product Overview: Recombinant Human arachidonate 15-lipoxygenase, type B is expressed inE. coliwith C-terminal His tag. The molecular weight of the recombinant human ALOX15B is 76 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: ALOX15B gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
• Purity: Greater than 95% as determined by SDS-PAGE.
• Concentration: 1.0 mg/mL.
• Supplied in: PBS, pH 7.4, 1 mM DTT and 20% glycerol.
• Storage: -80℃.

Gene Information

• Gene Name: ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens ]
• Synonyms: arachidonate 15-lipoxygenase, type B; ALOX15B; 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15S-lipoxygenase; 15-lipoxygenase 2; arachidonate 15-lipoxygenase 2; arachidonate omega(6) lipoxygenase; arachidonate 15-lipoxygenase type II
• Gene ID: 247
• mRNA Refseq: NM_001039130
• Protein Refseq: NP_001034219
• MIM: 603697
• UniProt ID: O15296
• Chromosome Location: 17p13.1
• Pathway: Arachidonic acid metabolism; Metabolic pathways
• Function: arachidonate 15-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity