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Recombinant Human Arachidonate 15-lipoxygenase, Type B, His-tagged

Cat. No.: ALOX15B-580H.
Product Overview: Recombinant Human arachidonate 15-lipoxygenase, type B is expressed inE. coliwith C-terminal His tag. The molecular weight of the recombinant human ALOX15B is 76 kDa.
Description: ALOX15B gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Source: E. coli.
Purity: Greater than 95% as determined by SDS-PAGE.
Concentration: 1.0 mg/mL.
Supplied in: PBS, pH 7.4, 1 mM DTT and 20% glycerol.
Storage: -80℃.
Gene Name: ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens ]
Synonyms: arachidonate 15-lipoxygenase, type B; ALOX15B; 15-LOX-2; arachidonate 15-lipoxygenase, second type; 15S-lipoxygenase; 15-lipoxygenase 2; arachidonate 15-lipoxygenase 2; arachidonate omega(6) lipoxygenase; arachidonate 15-lipoxygenase type II
Gene ID: 247
mRNA Refseq: NM_001039130
Protein Refseq: NP_001034219
MIM: 603697
UniProt ID: O15296
Chromosome Location: 17p13.1
Pathway: Arachidonic acid metabolism; Metabolic pathways
Function: arachidonate 15-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity

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