Recombinant Human Prostaglandin E Synthase PTGES-583H

Recombinant Human Prostaglandin E Synthase

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Recombinant Human Prostaglandin E Synthase

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Cat. No. : PTGES-583H
Product Overview : Recombinant Human PTGES isolated from a baculovirus overexpression system inSf21 cells. MW = 21 kDa.
Description : Prostaglandin E synthases (PGESs) are enzymes that convert cyclooxygenase (COX)-derived PGH2 to PGE2. There are three different PGES enzymes with distinct enzymatic properties, modes of expression, cellular and subcellular localizations, and intracellular functions, two of which are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein belonging to the membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.2 It requires glutathione as an essential cofactor for activity. mPGES-1 is up-regulated in response to various proinflammatory stimuli with a concomitant increased expression of COX-2 and is down-regulated by glucocorticoids.3 mPGES-1 gene knockout studies in mice have indicated a role for mPGES-1-generated PGE2 in female reproduction, inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. Therefore, mPGES-1 is a potential drug target for various diseases.
Source : Sf21 cells.
Purity : 16,000 x g supernatant.
Formulation : A solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.
Storage : ≥6 months at -80°C; avoid freeze/thaw cycles by aliquoting the protein and storing at -80°C.
Gene Name : PTGES prostaglandin E synthase [ Homo sapiens ]
Synonyms : PTGES; prostaglandin E synthase; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGC10317; MGST1-L1; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1; EC 5.3.99.3
Gene ID : 9536
mRNA Refseq : NM_004878
Protein Refseq : NP_004869
MIM : 605172
UniProt ID : O14684
Chromosome Location : 9q34.3
Pathway : Arachidonic acid metabolism; Metabolic pathways
Function : isomerase activity; prostaglandin-E synthase activity

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