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Recombinant Mouse Tnfrsf12a, Fc Chimera

Cat. No.: Tnfrsf12a-2085M
Product Overview: Recombinant Mouse Tnfsf12a is produced inHEK 293 Cells.The extracellular domain of mouse Fn14 (aa 1-75) is fused to the Fc portion of human IgG1. MW=34kDa.
Description: The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 has recently been described to bind TWEAK [Apo-3 Ligand], a member of the TNF family.
Source: HEK 293 Cells.
Purity: ≥95% (SDS-PAGE).
Concentration: 0.1mg/ml after reconstitution.
Formulation: Lyophilized. Contains PBS.
Endotoxin Content: <0.1EU/µg purified protein (LAL test; BioWhittaker).
Specificity: Binds human and mouse TWEAK.
Biological Activity: Inhibits TWEAK-mediated killing of Kym-1 target cells. Avoid freeze/thaw cycles.
Storage: Stable for at least 6 months after receipt when stored at -20°C.
Gene Name: Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a [ Mus musculus ]
Synonyms: Tnfrsf12a; tumor necrosis factor receptor superfamily, member 12a;FGF-inducible 14; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; fibroblast growth factor-regulated protein 2; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; type I transmembrane protein Fn14; Fn14; HPIP; C87282; TweakR; TWEAK-R; AI255180
Gene ID: 27279
mRNA Refseq: NM_001161746
Protein Refseq: NP_001155218
UniProt ID: Q9CR75
Chromosome Location: 17 A3.3
Pathway: Cytokine-cytokine receptor interaction
Function: protein binding; receptor activity

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