"Tnfrsf18" Related Products


Recombinant Mouse Tnfrsf18, Fc Chimera

Cat. No. : Tnfrsf18-2087M
Product Overview : Recombinant MouseTnfrsf18 Produced inHEK 293 cells.The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1. MW=45kDa (SDS-PAGE).
Description : GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies.
Source : HEK 293 cells.
Concentration : 1mg/ml after reconstitution.
Purity : ≥90% (SDS-PAGE).
Formulation : Lyophilized. Contains PBS.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Specificity : Binds mouse GITRL.
Term Storage : -20°C.
Handling : Stable for at least 6 months after receipt when stored at -20°C.
Stability : Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Gene Name : Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus ]
Synonyms : Tnfrsf18; tumor necrosis factor receptor superfamily, member 18; AITR; Gitr;tumor necrosis factor receptor superfamily member 18; OTTMUSP00000011817; OTTMUSP00000011818; glucocorticoid-induced TNFR-related protein
Gene ID : 21936
mRNA Refseq : NM_009400
Protein Refseq : NP_033426
UniProt ID : O35714
Chromosome Location : 4 E
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor binding

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