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Recombinant Mouse Tnfrsf18, Fc Chimera

Cat. No.: Tnfrsf18-2087M
Product Overview: Recombinant MouseTnfrsf18 Produced inHEK 293 cells.The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1. MW=45kDa (SDS-PAGE).
Description: GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies.
Source: HEK 293 cells.
Concentration: 1mg/ml after reconstitution.
Purity: ≥90% (SDS-PAGE).
Formulation: Lyophilized. Contains PBS.
Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Specificity: Binds mouse GITRL.
Term Storage: -20°C.
Handling: Stable for at least 6 months after receipt when stored at -20°C.
Stability: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Gene Name: Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus ]
Synonyms: Tnfrsf18; tumor necrosis factor receptor superfamily, member 18; AITR; Gitr;tumor necrosis factor receptor superfamily member 18; OTTMUSP00000011817; OTTMUSP00000011818; glucocorticoid-induced TNFR-related protein
Gene ID: 21936
mRNA Refseq: NM_009400
Protein Refseq: NP_033426
UniProt ID: O35714
Chromosome Location: 4 E
Pathway: Cytokine-cytokine receptor interaction
Function: protein binding; receptor binding

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