"RANGAP1" Related Products


Recombinant Human Ran GTPase Activating Protein 1, GST-tagged

Cat. No.: RANGAP1-682H
Product Overview: Recombinant human RanGAP1 produced inE. coliis fused to a GST-tag.
Description: RanGTPase-activating RanGAP1 was the first protein shown to be post-translationally modified with SUMO. In higher eukaryotes, the cellular localization of RanGAP1 is regulated by SUMOylation of its C-terminal domain. The target lysines of RanGAP1, as well as the C-terminus of mature SUMO-1, lie within mobile regions of the two proteins. Upon SUMOylation, RanGAP1 and SUMO-1 behave as "beads-on-a-string" joined by a flexible isopeptide tether and their structures and local dynamic features do not change significantly beyond the site of this covalent linkage.
Source/Host: E. coli.
Application: RanGAP1 acts as a very good control substrate for use in SUMOylation assays producing a product with a single SUMO modification as shown above.
Long Term Storage: -80°C.
Gene Name: RANGAP1 Ran GTPase activating protein 1 [ Homo sapiens ]
Synonyms: Ran GTPase activating protein 1; SD; Fug1; KIAA1835; MGC20266; RANGAP1; ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog; segregation distorter homolog (Drosophila); OTTHUMP00000198756; OTTHUMP00000198757; RanGAP1
Gene ID: 5905
mRNA Refseq: NM_002883
Protein Refseq: NP_002874
MIM: 602362
UniProt ID: P46060
Chromosome Location: 22q13
Pathway: Cell Cycle, Mitotic
Function: GTPase activator activity; Ran GTPase activator activity; protein binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.