"RANGAP1" Related Products

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Recombinant Human Ran GTPase Activating Protein 1, GST-tagged

Cat. No. : RANGAP1-682H
Product Overview : Recombinant human RanGAP1 produced inE. coliis fused to a GST-tag.
Description : RanGTPase-activating RanGAP1 was the first protein shown to be post-translationally modified with SUMO. In higher eukaryotes, the cellular localization of RanGAP1 is regulated by SUMOylation of its C-terminal domain. The target lysines of RanGAP1, as well as the C-terminus of mature SUMO-1, lie within mobile regions of the two proteins. Upon SUMOylation, RanGAP1 and SUMO-1 behave as "beads-on-a-string" joined by a flexible isopeptide tether and their structures and local dynamic features do not change significantly beyond the site of this covalent linkage.
Source/Host : E. coli.
Application : RanGAP1 acts as a very good control substrate for use in SUMOylation assays producing a product with a single SUMO modification as shown above.
Long Term Storage : -80°C.
Gene Name : RANGAP1 Ran GTPase activating protein 1 [ Homo sapiens ]
Synonyms : Ran GTPase activating protein 1; SD; Fug1; KIAA1835; MGC20266; RANGAP1; ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog; segregation distorter homolog (Drosophila); OTTHUMP00000198756; OTTHUMP00000198757; RanGAP1
Gene ID : 5905
mRNA Refseq : NM_002883
Protein Refseq : NP_002874
MIM : 602362
UniProt ID : P46060
Chromosome Location : 22q13
Pathway : Cell Cycle, Mitotic
Function : GTPase activator activity; Ran GTPase activator activity; protein binding

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