||Recombinant Mouse full length ERK2/MAPK2 (K52R) with N-terminal His6 tag, was expressed inE.coli. MW=42 kDa.
||ERK2 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of ERK2 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK2 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK2 translocates into the nucleus where it phosphorylates various transcription factors.
||25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 3 mM DTT.
||A suitable substrate of MEK1.
||>6 months at –80°C.
||Acute myeloid leukemia; Adherens junction; Aldosterone-regulated sodium reabsorption; Alzheimer"s disease; Axon guidance; Melanogenesis; Melanoma; NOD-like receptor signaling pathway; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Oocyte meiosis; Pancreatic cancer; Pathways in cancer; Prion diseases; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; TGF-beta signaling pathway; Thyroid cancer; Toll-like receptor signaling pathway; Type II diabetes mellitus; VEGF signaling pathway; Vascular smooth muscle contraction; mTOR signaling pathway