Recombinant Human CD274 Molecule, Fc Chimera

• Cat.No.: CD274-2142H
• Product Overview: Recombinant human B7H1 extracellular domain (C-terminus fused with murine IgG1 Fc)produced inmammalian cells contains 493 amino acids with predicted MW 56.06 KD x 2 (dimer), and 13 cysteines (Fc has 6). It also has 4 N-link glycosylation sites with MW increase up to 20 KD x 2 (dimer).

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: B7-H1 is a third member of the B7 family. It co-stimulates T-cell proliferation and interleukin-10 secretion. CD274 (Cluster of Differentiation 274) also known as PD-L1 (Programed Death Ligand-1) or B7-H1 is a protein which in humans is encoded by the CD274 gene.
• Purity: >90%.
• Recommended Storage Temperature: -70 °C.

Gene Information

• Gene Name: CD274 CD274 molecule [ Homo sapiens ]
• Synonyms: CD274; CD274 molecule; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; programmed cell death 1 ligand 1; CD274 antigen; Programmed cell death 1 ligand 1; Programmed death ligand 1; PDCD1 ligand 1; B7 homolog 1; OTTHUMP00000021029
• Gene ID: 29126
• mRNA Refseq: NM_014143
• Protein Refseq: NP_054862
• MIM: 605402
• UniProt ID: Q9NZQ7
• Chromosome Location: 9q24
• Pathway: Cell adhesion molecules (CAMs); Signaling in Immune system
• Function: protein binding; receptor activity