Recombinant Human Syndecan 4, Fc Chimera

• Cat.No.: SDC4-2425H
• Product Overview: Recombinant extracellular domain of human syndecan-4 (aa 1-145) produced inHEK 293 cellsis fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Cat. No.: SDC4-2425H
• Description: Syndecan-4 is a type I integral membrane heparan sulfate proteoglycan (HSPG), which was originally isolated from cloned rat microvascular endothelial cells as an antithrombin-binding molecule, and is now known to be a member of the syndecan family. Syndecan-4 binds to basic fibroblast growth factor (bFGF), midkine, and tissue factor pathway inhibitor via its heparan sulfate chains, and is thought to be involved in various biologic functions such as signaling of bFGF, anticoagulation, and focal adhesion formation. A previous study demonstrated that syndecan-4 is expressed in various tissues, and its level of expression in the kidney is stronger than those of other syndecan family members. Thus, syndecan-4 is thought to play certain roles in maintaining renal function. Moreover, it has been reported that proteoglycans, especially sulfated proteoglycans, are involved in organogenesis of the kidney.
• Source/Host: HEK 293 cells.
• Concentration: 1mg/ml.
• Purity: ≥90% (SDS-PAGE).
• Endotoxin Content: <0.1EU/µg protein (LAL-test).
• Formulation: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: SDC4 syndecan 4 [ Homo sapiens ]
• Synonyms: syndecan 4; SYND4; MGC22217; SDC4; syndecan 4; Amphiglycan; amphiglycan; ryudocan; ryudocan amphiglycan; ryudocan core protein; syndecan 4; syndecan proteoglycan 4; OTTHUMP00000031788; syndecan 4 (amphiglycan, ryudocan)
• Gene ID: 6385
• mRNA Refseq: NM_002999
• Protein Refseq: NP_002990
• MIM: 600017
• UniProt ID: P31431
• Chromosome Location: 20q12
• Pathway: Cell adhesion molecules (CAMs); ECM-receptor interaction
• Function: cytoskeletal protein binding; molecular_function; thrombospondin receptor activity