Native Human Coagulation Factor XI

• Cat.No.: F11-2466H
• Product Overview: Human Factor XI is a two-chain glycoprotein prepared from fresh human plasma using several chromatographic steps.MW160kDa.

Specification

• Cat. No.: F11-2466H
• Description: Human coagulation factor XI, encoded by the F11 gene, is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
• Source: Human plasma
• Concentration: 1.0 mg/ml
• Purity: >95% by SDS-PAGE analysis
• Form: Frozen liquid.
• Shipping Information: Recommended Storage: -70oC; Shipping Conditions: Dry ice; Minimum Shelf Life: 3 years from delivery.

Gene Information

• Gene Name: F11 coagulation factor XI [ Homo sapiens ]
• Official Symbol: F11
• Synonyms: F11; coagulation factor XI; FXI; MGC141891; Coagulation factor XI; Plasma thromboplastin antecedent; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; EC 3.4.21.27; EC 3.4.21
• Gene ID: 2160
• mRNA Refseq: NM_000128
• Protein Refseq: NP_000119
• MIM: 264900
• UniProt ID: P03951
• Chromosome Location: 4q35
• Pathway: Blood Clotting Cascade; Complement and coagulation cascades; Formation of Fibrin Clot (Clotting Cascade); Hemostasis; Intrinsic Pathway
• Function: heparin binding; protein binding;serine-type endopeptidase activity