Expand| Cat. No. : | CLK1-676H |
| Product Overview : | Recombinant human CDC-Like Kinase 1 catalytic domain (aa 129-484) with GST tag was expressed inE. coli.MW = 70.1 kDa. |
| Description : | CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors. |
| Source : | E. coli. |
| Formulation : | Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2mM DTT + 50% glycerol. |
| Specific Activity : | 79 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml. |
| Storage & Stability : | Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| Gene Name : | CLK1 CDC-like kinase 1 [ Homo sapiens ] |
| Synonyms : | CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1 |
| Gene ID : | 1195 |
| mRNA Refseq : | NM_001162407 |
| Protein Refseq : | NP_001155879 |
| MIM : | 601951 |
| UniProt ID : | P49759 |
| Chromosome Location : | 2q33 |
| Function : | ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity |
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