Recombinant Human CDC-like Kinase 1, GST-tagged CLK1-676H

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Recombinant Human CDC-like Kinase 1, GST-tagged

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Cat. No. :	CLK1-676H
Product Overview :	Recombinant human CDC-Like Kinase 1 catalytic domain (aa 129-484) with GST tag was expressed inE. coli.MW = 70.1 kDa.
Description :	CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
Source :	E. coli.
Formulation :	Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2mM DTT + 50% glycerol.
Specific Activity :	79 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
Storage & Stability :	Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
PDB rendering based on 1z57. :

Gene Name :	CLK1 CDC-like kinase 1 [ Homo sapiens ]
Synonyms :	CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1
Gene ID :	1195
mRNA Refseq :	NM_001162407
Protein Refseq :	NP_001155879
MIM :	601951
UniProt ID :	P49759
Chromosome Location :	2q33
Function :	ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity