Recombinant Human CDC-like Kinase 1, GST-tagged CLK1-676H

Cat. No.:	CLK1-676H
Product Overview:	Recombinant human CDC-Like Kinase 1 catalytic domain (aa 129-484) with GST tag was expressed inE. coli.MW = 70.1 kDa.
Description:	CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
Source:	E. coli.
Formulation:	Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2mM DTT + 50% glycerol.
Specific Activity:	79 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
Storage & Stability:	Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.

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Gene Name:	CLK1 CDC-like kinase 1 [ Homo sapiens ]
Synonyms:	CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1
Gene ID:	1195
mRNA Refseq:	NM_001162407
Protein Refseq:	NP_001155879
MIM:	601951
UniProt ID:	P49759
Chromosome Location:	2q33
Function:	ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity