Recombinant Human CDC-like Kinase 1, GST-tagged CLK1-676H

Recombinant Human CDC-like Kinase 1, GST-tagged


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Recombinant Human CDC-like Kinase 1, GST-tagged

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Cat. No. : CLK1-676H
Product Overview : Recombinant human CDC-Like Kinase 1 catalytic domain (aa 129-484) with GST tag was expressed inE. coli.MW = 70.1 kDa.
Description : CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
Source : E. coli.
Formulation : Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2mM DTT + 50% glycerol.
Specific Activity : 79 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
Storage & Stability : Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
PDB rendering based on 1z57. :

Gene Name : CLK1 CDC-like kinase 1 [ Homo sapiens ]
Synonyms : CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC
Gene ID : 1195
mRNA Refseq : NM_001162407
Protein Refseq : NP_001155879
MIM : 601951
UniProt ID : P49759
Chromosome Location : 2q33
Function : ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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