"MAPKAPK5" Related Products

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Recombinant Human MAPKAPK5, GST-His

Cat. No.: MAPKAPK3-695H
Product Overview: Recombinant, human MAPKAPK5 is fused at the N-terminus to a GST-His 6-thrombin cleavage site tag and expressed inS. frugiperda insect cellsusing a baculovirus expression system. MAPKAPK5 is a member of the serine/threonine kinase family that mediates stress-induced small heat shock protein 27 phosphorylation.
Description: MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source: S. frugiperda insect cells.
Form: Liquid.
Formulation: In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol, pH 8.0.
Molar Mass: 84116 Da.
Specific Activity: ≥2 U/mg protein.
Unit Definition: One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to tetra(LRRWSLG) per min at 30°C using concentration of 0.1 μM ATP.
Purity: ≥90% by SDS-PAGE.
Storage: ≤ -70oC. Ship: Dry Ice Only.
Gene Name: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [ Homo sapiens ]
Synonyms:
MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; PRAK; EC 2.7.11.1
Gene ID: 8550
mRNA Refseq: NM_003668
Protein Refseq: NP_003659
MIM: 606723
UniProt ID: Q8IW41
Chromosome Location: 12q24.12-q24.13
Pathway: MAPK signaling pathway
Function: ATP binding; MAP kinase kinase activity; nucleotide binding; protein

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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