Recombinant Human Janus Kinase 3, GST-His

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Recombinant Human Janus Kinase 3, GST-His

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Cat. No. : JAK3-2657H
Product Overview : Recombinant human JAK3 was fused at the N-termiunus to a GST-His6-thrombin cleavage site sequence and expressed inS.frugiperdainsect cells using a baculovirus expression system. MW = 68379 Da.
Description : JAK3 is a member of the Janus family of tyrosine kinases and plays an important role in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family.
Source : S.frugiperda.
Form : Liquid. In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Specific Activity : ≥6.0 U/mg protein.
Unit Definition : One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to R11-TRK-C-derived peptide (R11-VYSTDYYRLFNPS) per min at 30°C using variable concentrations of ATP (0.1-1.11 µM).
Storage : ≤ -70℃. Avoid freeze/thaw.
PDB rendering based on 1yvj. :

Gene Name : JAK3 Janus kinase 3 [ Homo sapiens ]
Synonyms : JAK3; Janus kinase 3; JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC 2.7.10.2
Gene ID : 3718
mRNA Refseq : NM_000215
Protein Refseq : NP_000206
MIM : 600173
UniProt ID : P52333
Chromosome Location : 19p13.1
Pathway : Chemokine signaling pathway; Jak-STAT signaling pathway; Primary immunodeficiency
Function : ATP binding; Janus kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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