Recombinant Bovine Interleukin 6 (Interferon, Beta 2)

Cat. No.: IL6-241B
Product Overview: Recombinant Bovine IL-6 was expressed inYeast. MW= 20.7 kDa (179 aa).
Description: Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.
Source: Yeast.
Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Purification: Ion-exchange chromatography.
Purity: >95% as visualized by SDS-PAGE analysis.
Amino Acid Sequence: GPLGEDFKND TTPGRLLLTT PEKTEALIKR MVDKISAMRK EICEKNDECE SSKETLAENK LNLPKMEEKD GCFQSGFNQA ICLIRTTAGL LEYQIYLDYL QNEYEGNQEN VRDLRKNIRT LIQILKQKIA DLITTPATNT DLLEKMQSSN EWVKNAKIIL ILRNLENFLQ FSLRAIRMK.
Bioactivity: Currently, there is no known bioassay for bovine IL-6.
Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Gene Name: IL6 interleukin 6 (interferon, beta 2) [ Bos taurus ]
Synonyms: interleukin 6 (interferon, beta 2); IL6; interleukin-6; IL-6
Gene ID: 280826
mRNA Refseq: NM_173923.2
Protein Refseq: NP_776348.1
UniProt ID: P26892
Chromosome Location: 4
Pathway: Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Graft-versus-host disease; Hematopoietic cell lineage; Hypertrophic cardiomyopathy (HCM); Intestinal immune network for IgA production; Jak-STAT signaling pathway; NOD-like receptor signaling pathway; Pathways in cancerPrion diseases; Toll-like receptor signaling pathway
Function: cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding

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