Recombinant Equine Interleukin 6 (Interferon, Beta 2)

Cat. No. : IL6-258E
Product Overview : Recombinant Equine IL-6 was expressed inYeast. MW= 20.6 kDa (181 aa).
Description : Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.
Source : Yeast.
Formulation/ Reconstitution : Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Purification : Ion-exchange chromatography.
Purity : >95% as visualized by SDS-PAGE analysis.
Amino Acid Sequence : TPLPLGEDET TSNGPLLTTA DKTKQHIKYI LGKISALKNE MCNNFSKCEN SKEVLAENNL NLPKMAEKDG CFQSGFNQET CLMKITTGLS EFQIYLEYLQ NEFKGEKENI KTMQISTKVL VQILMQKMKN PEVTTPDPTA KSSLLAKLHS QNEWLKNTTT HLILRSLEDF LQFSLRAVRI M.
Bioactivity : The biological activity of recombinant equine IL-6 was measured in a cell proliferation assay using the mouse B9 cell line. The ED50 for this effect is typically0.05 – 1.0 ng/mL.
Stability And Storage : Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
Gene Name : IL6 interleukin 6 (interferon, beta 2) [ Equus caballus ]
Synonyms : interleukin 6 (interferon, beta 2); IL6; IL-6; interleukin-6; interleukin 6
Gene ID : 100034196
mRNA Refseq : NM_001082496.1
Protein Refseq : NP_001075965.1
UniProt ID : Q95181
Chromosome Location : 4
Pathway : Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Graft-versus-host disease; Hematopoietic cell lineage; Hypertrophic cardiomyopathy (HCM); Intestinal immune network for IgA production; Jak-STAT signaling pathway; NOD-like receptor signaling pathway; Pathways in cancer; Prion diseases; Toll-like receptor signaling pathway

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