|Cat. No. :
||Furin is a protein that in humans is encoded by the FURIN gene. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).
|Preparation Note :
||Isolated from Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus carrying truncated human furin.
|Biochem/physiol Actions :
||Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells.
|Unit Definition :
||One unit is defined as the amount of Furin that will release 1 pmole of AMC from the fluorogenic peptide Boc-RVRR-AMC in 1 minute at 30 °C.
|Physical Form :
||Solution in 10 mM MES, pH 7.0 at 25 °C, 1 mM CaCl2, 50% glycerol.
||buffered aqueous solution.
|Storage Temp :