Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)


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Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme)

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Cat. No. : FURIN-720H
Description : Furin is a protein that in humans is encoded by the FURIN gene. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).
Source : Sf9.
Preparation Note : Isolated from Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus carrying truncated human furin.
Biochem/physiol Actions : Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells.
Unit Definition : One unit is defined as the amount of Furin that will release 1 pmole of AMC from the fluorogenic peptide Boc-RVRR-AMC in 1 minute at 30 °C.
Physical Form : Solution in 10 mM MES, pH 7.0 at 25 °C, 1 mM CaCl2, 50% glycerol.
Form : buffered aqueous solution.
Concentration : ≥2,000 unit/Ml.
Storage Temp : −70°C.
PDB rendering based on 1p8j. :

Gene Name : FURIN furin (paired basic amino acid cleaving enzyme) [ Homo sapiens ]
Synonyms : FURIN; furin (paired basic amino acid cleaving enzyme); FUR; PACE; SPC1; PCSK3; FES upstream region; dibasic processing enzyme; dibasic-processing enzyme; furin, membrane associated receptor protein; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue-cleaving enzyme; EC; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
Gene ID : 5045
mRNA Refseq : NM_002569
Protein Refseq : NP_002560
MIM : 136950
UniProt ID : P09958
Chromosome Location : 15q26.1
Pathway : Metabolism of proteins; Signaling by Notch; Signaling by PDGF; Signaling by TGF beta; Signalling by NGF
Function : endopeptidase activity; metal ion binding; nerve growth factor binding; peptidase activity; peptide binding; protease binding; protein binding; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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