"BTLA" Related Products


Recombinant Human B and T Lymphocyte Associated, His-tagged

Cat. No. : BTLA-3037H
Product Overview : Recombinant Human BTLA protein was expressed in E.coli with His-tag at the N-terminus. The molecular weight is 32689,8 Da.
Description : B and T lymphocyte associated is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
Sequences of amino acids : 25-289 aa
Formulation : Supplied in 20 mM Tris-HCl, 0.5 M NaCl, 1 mM 2-mercaptoethanol, pH:8.0 and contains not preservatives.
PDBrendering based on 2aw2. :

Gene Name : BTLA B and T lymphocyte associated [ Homo sapiens ]
Synonyms : BTLA1; CD272; FLJ16065; MGC129743; B- and T-lymphocyte attenuator; B and T lymphocyte attenuator; B- and T-lymphocyte-associated protein
Gene ID : 151888
mRNA Refseq : NM_181780
Protein Refseq : NP_861445
MIM : 607925
UniProt ID : Q7Z6A9
Chromosome Location : 3q13.2
Pathway : Signaling in Immune system
Function : protein binding; receptor activity

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