|Cat. No. :
|Product Overview :
||Recombinant mouse cytosolic thioredoxin with a 6-His tag is fully active with thioredoxin reductase. Mr is approximately 12,000 D.
||This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3" UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
||Purified via immunoaffinity column chromatography, it contains no E. coli Thioredoxin-S2.
||100 μg of protein, salt-free, lyophilized from 0.5% NH4CO3.
||Add 100 μL of filtered deionized water or physiological buffer to generate a 1 mg/mL solution.
||Store the lyophilized product at 2°- 8°C.