Recombinant Human CRK, His-tagged
Cat.No. : | CRK-2854H |
Product Overview : | Recombinant human CRK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 25.0 kDa (224aa), confirmed by MALDI-TOF. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CRK-2854H |
Description : | CRK is a member of signaling adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein is involved in many cellular processes including apoptosis, proliferation, and differentiation. It has a modular domain architecture consisting of an SH2 followed by two SH3 domains (src-homology domains). The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. |
Source : | E.coli. |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGR |
Purity : | > 95% by SDS – PAGE. |
Form : | Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol. |
Concentration : | 0.5 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | CRK v-crk sarcoma virus CT10 oncogene homolog (avian) [ Homo sapiens ] |
Synonyms : | CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); CRKII; adapter molecule crk; p38; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; avian sarcoma virus CT10 (v-crk) oncogene homolog |
Gene ID : | 1398 |
mRNA Refseq : | NM_005206 |
Protein Refseq : | NP_005197 |
MIM : | 164762 |
UniProt ID : | P46108 |
Chromosome Location : | 17p13.3 |
Pathway : | Bacterial invasion of epithelial cells; Chemokine signaling pathway; Chronic myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Insulin signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Shigellosis |
Function : | SH2 domain binding; SH3/SH2 adaptor activity; protein binding; protein phosphorylated amino acid binding |
Products Types
◆ Recombinant Protein | ||
Crk-2313M | Recombinant Mouse Crk Protein, Myc/DDK-tagged | +Inquiry |
CRK-1886H | Recombinant Human CRK Protein, GST-tagged | +Inquiry |
CRK-1260R | Recombinant Rat CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
CRK-661H | Recombinant Human CRK Protein, His (Fc)-Avi-tagged | +Inquiry |
CRK-1603R | Recombinant Rat CRK Protein | +Inquiry |
◆ Lysates | ||
CRK-7276HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
CRK-7277HCL | Recombinant Human CRK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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