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|Product Overview :
||Recombinant Human MMP11 was produced in E.coli with a GST-His tag. MW = 79817 Da (33-488 aa).
||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP"s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
||Supplied in 20 mM Tris-HCl, 0.5 M NaCl, 100 mM imidazole, 1 mM 2-mercaptoethanol; pH 8.0 and contains not preservatives.
||ELISA, WB, Antibody Production, Protein array.