Recombinant Human WD Repeat Domain 4, T7-tagged

• Cat.No.: WDR4-847H
• Product Overview: Recombinant Human WDR4 was produced in E.coli with a T7 tag at N-terminus. MW = 45490 Da (1-266 aa).

Specification

• Cat. No.: WDR4-847H
• Description: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.
• Source: E.coli.
• Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.
• Purity: 90%.
• Clonality: N/A.
• Applications: MS. SDS.

Gene Information

• Gene Name: WDR4 WD repeat domain 4 [ Homo sapiens ]
• Synonyms: WDR4 WD repeat domain 4; TRM82; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; WD repeat-containing protein 4
• Gene ID: 10785
• mRNA Refseq: NM_018669
• Protein Refseq: NP_061139
• MIM: 605924
• UniProt ID: P57081
• Chromosome Location: 21q22.3
• Function: protein binding; contributes_to tRNA (guanine-N7-)-methyltransferase activity