|Product Overview:||Recombinant Human DUSP1 (1-340 aa) is expressed in E.Coli with a His tag at N-terminus.|
|Description:||The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.|
|Formulation:||10 mM Tris. pH 8.0. 0.002% NaN3. 3mM NaCl. 2.5mM Imidazole.|
|Gene Name:||DUSP1 dual specificity phosphatase 1 [ Homo sapiens ]|
|Synonyms:||DUSP1; dual specificity phosphatase 1; CL100, HVH1, MKP-1, MKP1, PTPN10; MAP kinase phosphatase 1; dual specificity protein phosphatase 1; dual specificity protein phosphatase hVH1; mitogen-activated protein kinase phosphatase 1; protein-tyrosine phosphatase CL100; serine/threonine specific protein phosphatase; EC 22.214.171.124; EC 126.96.36.199|
|Pathway:||MAPK signaling pathway|
|Function:||MAP kinase tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity; protein binding|
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