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Recombinant Human NFKB1, His-tagged

Cat.No. : NFKB1-633H
Product Overview : Recombinant Human NFKB1 isproduced inSf21 cellsand fused to a His-tag.
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  • Gene Information
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Cat. No. : NFKB1-633H
Description : This gene encodes a 105 kDa protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kDa protein. The 105 kDa protein is a Rel protein-specific transcription inhibitor and the 50 kDa protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Source : Sf21 cells.
Concentration : 0.2mg/ml.
Formulation : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
Specific Activity : ~1ng is required for high mobility shift assay. ~5ng are required for reconstituted transcription assays.
Storage : -80°C. After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Gene Name : NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [ Homo sapiens ]
Synonyms : NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA binding factor KBF1; DNA-binding factor KBF1; NF-kappabeta; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; p50; KBF1; p105; EBP-1; MGC54151; NFKB-p50; NF-kappaB; NFKB-p105; NF-kappa-B; DKFZp686C01211; NFKB1
Gene ID : 4790
mRNA Refseq : NM_001165412
Protein Refseq : NP_001158884
MIM : 164011
UniProt ID : P19838
Chromosome Location : 4q24
Pathway : Acute myeloid leukemia; Adipocytokine signaling pathway; B cell receptor signaling pathway; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Leishmania infection; NOD-like receptor signaling pathway; Pancreatic cancer; RIG-I-like receptor signaling pathway; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signalling by NGF
Function : promoter binding; protein binding; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of NFKB1 protein in autoimmune diseases? 10/17/2019

NFKB1 protein is involved in the occurrence and progression of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

What is the relationship between NFKB1 protein and apoptosis? 08/15/2019

NFKB1 protein plays a complex role in apoptosis and may promote or inhibit the occurrence of apoptosis.

What drugs interact with the NFKB1 protein? 04/16/2019

A variety of drugs have been developed that target the NFKB1 protein and its downstream signaling pathways, such as inhibiting NFKB1 activation or inhibiting the transcriptional activity of NFKB1 downstream genes.

Does the NFKB1 protein study have implications for new drug development? 03/01/2019

The protein plays a key role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of NFKB1 protein will help the development of new drugs, such as targeted drugs targeting NFKB1 protein and its signaling pathway may be applied to the treatment of related diseases.

Is there a potential application of NFKB1 protein in the design of immune vaccines? 01/18/2019

This protein plays an important role in the activation of immune cells and the regulation of inflammation, so it can be used in immune vaccine design to enhance immune effects.

Why does NFKB1 protein have a pattern of expression in immune cells? 01/17/2019

The expression pattern of NFKB1 protein in immune cells is regulated by different stimuli and environments, and participates in the activation and regulation of immune cells.

Customer Reviews (3)

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Reviews
06/16/2022

    Potent biological activity of NFKB1, combined with its high purity, provides accurate and reliable experimental data for the research field.

    04/22/2022

      The short half-life and high clearance of NFKB1 allow its rapid action and rapid clearance in vivo, improving therapeutic efficiency.

      05/21/2019

        Beacuse production process of NFKB1 realizes the minimization of waste and the minimal impact on the environment, which is truly green production.

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