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| Cat.No.: | NOG-117HG |
| Product Overview: | Recombinant Human NOG, Gln28-Cys232, Fused with Human IgG1 at C-terminal was produced in NS0 cell under cGMP guidelines. |
| Source: | NS0 |
| Species: | Human |
| Tag : | Fc |
| Form: | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Bio-activity: | Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.1-0.4 μg/mL in the presence of 30 ng/mL of Recombinant Human BMP‑4. |
| Molecular Mass: | Predicted Molecular Mass: 49.6 (monomer) kDa SDS-PAGE: 58-62 kDa, reducing conditions 130-135 kDa, non-reducing conditions |
| Endotoxin: | <0.10 EU per 1 μg of the protein by the LAL method. |
| Purity: | >90%, by SDS-PAGE with silver staining, under reducing conditions. |
| Storage: | Avoid repeated freeze-thaw cycles. 12 months, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Reconstitution: | Reconstitute at 100 μg/mL in PBS. |
| Quality Statement: | Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing. |
| Shipping: | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
| Gene Name: | NOG noggin [ Homo sapiens ] |
| Official Symbol: | NOG |
| Synonyms: | NOG; noggin; symphalangism 1 (proximal); SYM1; SYNS1; |
| Gene ID: | 9241 |
| mRNA Refseq: | NM_005450 |
| Protein Refseq: | NP_005441 |
| MIM: | 602991 |
| UniProt ID: | Q13253 |
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