Mouse Anti-Human CD40 Monoclonal Antibody
Cat.No. : | DMAB6033MH |
Product Overview : | Monoclonal Anti-human CD40 |
- Specification
- Gene Information
- Related Products
Antigen Description : | CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes,dendritic cells,and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily,which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L,CD154,gp39,and TRAM) belongs to the TNF gene family and is expressed more widely than CD40,predominantly on activated CD4+T cells. Following interaction with CD40 ligand,CD40 mediates a number of major immunoregulatory functions,central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion,proliferation,immunoglobulin isotype switch,and secretion. |
specificity : | human CD40 |
Target : | CD40 |
Immunogen : | anti-μ activated tonsillar human B cells |
Host : | Mouse |
Isotype : | IgG1 |
species : | Human |
Clone : | nBc 90 |
Purification : | QMA Hyper D ion exchange chromatography |
Applications : | N/A |
Usage recommendation : | This monoclonal antibody may be used between 1-10 μg/ml. 10ng/ml for cellular activation. Optimal dilution should be determined by each laboratory for each application. Coupled antibody: to maintain RT before use. |
Storage : | -20 °C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Gene Name : | CD40 CD40 molecule,TNF receptor superfamily member 5 [ Homo sapiens ] |
Official Symbol : | CD40 |
Synonyms : | CD40;p50;Bp50;CDW40;TNFRSF5;tumor necrosis factor receptor superfamily member 5;CD40L receptor;CD40 type II isoform;B cell-associated molecule;B cell surface antigen CD40;B-cell surface antigen CD40;CD40 antigen (TNF receptor superfamily member 5);tumor n |
Gene ID : | 958 |
mRNA Refseq : | NM_001250 |
Protein Refseq : | NP_001241 |
MIM : | 109535 |
UniProt ID : | P25942 |
Chromosome Location : | 20q12-q13.2 |
Pathway : | Adaptive Immune System;Allograft rejection;Asthma;Autoimmune thyroid disease;CD40/CD40L signaling;Cell adhesion molecules (CAMs);Cytokine-cytokine receptor interaction; |
Function : | enzyme binding;protein binding;receptor activity;signal transducer activity |
Products Types
◆ Recombinant Protein | ||
CD40-679H | Recombinant Human CD40 Protein, His-tagged | +Inquiry |
CD40-630M | Recombinant Mouse CD40 Protein | +Inquiry |
Cd40-1462M | Recombinant Mouse Cd40 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD40-371H | Active Recombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated | +Inquiry |
CD40-1087H | Recombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CD40-001CCL | Recombinant Canine CD40 cell lysate | +Inquiry |
CD40-1262RCL | Recombinant Rat CD40 cell lysate | +Inquiry |
CD40-1831MCL | Recombinant Mouse CD40 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.
As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.
Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.
Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.
Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.
Customer Reviews (3)
Write a reviewIts utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.
The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.
CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.
Ask a Question for All CD40 Products
Required fields are marked with *
My Review for All CD40 Products
Required fields are marked with *
Inquiry Basket