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Mouse Anti-Human CD40 Monoclonal Antibody

Cat.No. : DMAB6033MH
Product Overview : Monoclonal Anti-human CD40
  • Specification
  • Gene Information
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Antigen Description : CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes,dendritic cells,and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily,which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L,CD154,gp39,and TRAM) belongs to the TNF gene family and is expressed more widely than CD40,predominantly on activated CD4+T cells. Following interaction with CD40 ligand,CD40 mediates a number of major immunoregulatory functions,central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion,proliferation,immunoglobulin isotype switch,and secretion.
specificity : human CD40
Target : CD40
Immunogen : anti-μ activated tonsillar human B cells
Host : Mouse
Isotype : IgG1
species : Human
Clone : nBc 90
Purification : QMA Hyper D ion exchange chromatography
Applications : N/A
Usage recommendation : This monoclonal antibody may be used between 1-10 μg/ml. 10ng/ml for cellular activation. Optimal dilution should be determined by each laboratory for each application. Coupled antibody: to maintain RT before use.
Storage : -20 °C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name : CD40 CD40 molecule,TNF receptor superfamily member 5 [ Homo sapiens ]
Official Symbol : CD40
Synonyms : CD40;p50;Bp50;CDW40;TNFRSF5;tumor necrosis factor receptor superfamily member 5;CD40L receptor;CD40 type II isoform;B cell-associated molecule;B cell surface antigen CD40;B-cell surface antigen CD40;CD40 antigen (TNF receptor superfamily member 5);tumor n
Gene ID : 958
mRNA Refseq : NM_001250
Protein Refseq : NP_001241
MIM : 109535
UniProt ID : P25942
Chromosome Location : 20q12-q13.2
Pathway : Adaptive Immune System;Allograft rejection;Asthma;Autoimmune thyroid disease;CD40/CD40L signaling;Cell adhesion molecules (CAMs);Cytokine-cytokine receptor interaction;
Function : enzyme binding;protein binding;receptor activity;signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CD40-targeted therapies be used in the treatment of infectious diseases? 05/31/2022

CD40 agonists have the potential to enhance immune responses against infectious agents, but their clinical use in this context is an area of ongoing research.

Are there any approved drugs targeting CD40 for clinical use? 05/07/2021

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting CD40. However, clinical trials were ongoing for CD40-targeted therapies.

Can CD40-targeted therapies be used in combination with other cancer treatments? 04/24/2019

Yes, CD40-targeted therapies are often investigated in combination with other treatments like checkpoint inhibitors or chemotherapy to enhance their effectiveness.

What are the potential side effects of CD40-targeted therapies in cancer treatment? 09/25/2018

Side effects may include flu-like symptoms, cytokine release syndrome, and immune-related adverse events, which can be managed with supportive care and close monitoring.

Are there ongoing clinical trials exploring CD40-targeted therapies for atherosclerosis? 04/25/2017

Research on CD40-targeted therapies for atherosclerosis is still in the experimental stages and not yet in advanced clinical trials.

Customer Reviews (3)

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Reviews
10/28/2021

    Its utilization in this technique has allowed for precise visualization and determination of protein structures with remarkable clarity and resolution.

    08/11/2021

      The reliable and high-quality results obtained using CD40 protein make it an excellent choice for researchers studying protein structures.

      10/07/2018

        CD40 protein has proved to be an invaluable tool in protein electron microscopy structure analysis.

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