Recombinant Active Human EGFR (D746-750 G724S) Mutant Protein, GST-tagged

Cat.No. : EGFR-24H
Product Overview : Recombinant human EGFR (D746-750 G724S) (668-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Source : Insect cell
Species : Human
Tag : GST
Molecular Mass : Approx 89~100 kDa
Purity : > 70%
Stability : One year at -70 centigrade from data of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μL
Storage Buffer : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol.
Shipping : Dry ice
Protein length : 668-end
Gene Name : EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
Official Symbol : EGFR
Synonyms : EGFR; epidermal growth factor receptor; ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; epidermal growth factor receptor; EGFR vIII; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EC 2.7.10.1
Gene ID : 1956
mRNA Refseq : NM_005228
Protein Refseq : NP_005219
MIM : 131550
UniProt ID : P00533

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Reviews
09/05/2022

    The powerful biological activity of EGFR combined with its high purity makes the experimental results highly reproducible, which is of great significance in the field of scientific research.

    09/26/2019

      Due to the short half-life and high clearance characteristics of EGFR, they can better adapt to the needs of clinical treatment and provide more treatment options for patients.

      03/23/2019

        The production process of EGFR uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and reduces the consumption of human and material resources.

        Q&As (6)

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        What biological processes of human embryonic development and tissue regeneration is EGFR associated with? 10/07/2019

        It is associated with biological processes in human embryonic development and tissue regeneration.

        Why does EGFR-inhibiting drug therapy have adverse reactions? 09/25/2019

        EGFR inhibits adverse drug reactions such as rash, inflammation, and diarrhea during drug treatment.

        What is the role of EGFR in tumor treatment? 08/27/2019

        The role of EGFR in tumor treatment is to act as a molecular marker and can be used as a prognostic indicator and monitor tumor progression; at the same time, EGFR mutations can also be targeted for targeted therapy.

        What are the general methods used for EGFR gene mutation testing? 03/22/2019

        EGFR gene mutation detection generally uses PCR, fluorescence in situ hybridization, and direct sequencing.

        What other drugs can EGFR inhibitors be combined with to increase efficacy? 02/21/2019

        The combination of EGFR inhibitors with chemotherapy drugs, radiotherapy, immunotherapy, etc. can increase the efficacy of treatment and reduce the occurrence of adverse reactions.

        How do EGFR mutations affect the efficacy of targeted therapies? 02/04/2019

        EGFR mutations can have a significant impact on the efficacy of targeted therapies, and patients with mutations have higher response rates.

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