Recombinant Cynomolgus IL17A protein, His-Avi-tagged
Cat.No. : | IL17A-056C |
Product Overview : | Recombinant Cynomolgus IL17A Protein is expressed from mammalian with a His and avi Tag at the C-terminal. It contains Gly24-Ala155. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. |
Source : | HEK293 |
Species : | Cynomolgus |
Tag : | His-Avi |
Form : | Supplied as 0. 22um filtered solution in PBS (pH 7. 4). |
Molecular Mass : | The Cynomolgus IL17A Protein has a calculated MW of 18. 2kDa. As a result of glycosylation, the protein migrates as 26-32kDa based on Bis-Tris PAGE. |
Protein length : | It contains Gly24-Ala155. |
Endotoxin : | Less than 0. 1EU per ug by the LAL method. |
Purity : | > 95% as determined by Bis-Tris PAGE |
Storage : | The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL17A interleukin 17A [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | IL17A |
Synonyms : | CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A |
Gene ID : | 102119976 |
mRNA Refseq : | XM_005552759. 2 |
Protein Refseq : | XP_005552816. 1 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
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