Recombinant Cynomolgus Monkey FXN Protein (81-210 aa), His-tagged
Cat.No. : | FXN-1060M |
Product Overview : | Recombinant Cynomolgus Monkey (Macaca fascicularis) (Crab-eating macaque) FXN Protein (81-210 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
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- Gene Information
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Description : | Promotes the biosynthesis of he and assbly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1. |
Source : | E. coli |
Species : | Cynomolgus Monkey |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 18.2 kDa |
Protein length : | 81-210 aa |
AA Sequence : | SGTLGHPGSLDDTTYERLAEETLDS LAEFFEDLADKPYTFEDYDVSFGSG VLTVKLGGDLGTYVINKQTPNKQIW LSSPSSGPKRYDRTGKNWVYSHDGV SLHELLGAELTKALKTKLDLSSLAY SGKDA |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
UniProt ID : | Q8HXX9 |
UniProt ID : | Q8HXX9 |
Products Types
◆ Recombinant Protein | ||
FXN-3398M | Recombinant Mouse FXN Protein, His (Fc)-Avi-tagged | +Inquiry |
Fxn-1218R | Recombinant Rat Fxn Protein, His-tagged | +Inquiry |
Fxn-3112M | Recombinant Mouse Fxn Protein, Myc/DDK-tagged | +Inquiry |
FXN-1397M | Recombinant Mouse FXN Protein (78-207 aa), His-tagged | +Inquiry |
FXN-1592R | Recombinant Rhesus Macaque FXN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FXN-6108HCL | Recombinant Human FXN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.
FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.
FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.
FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.
FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.
Customer Reviews (3)
Write a reviewCustomer service was courteous and efficient, guiding us through the product selection process with expertise.
The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.
Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.
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