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Recombinant Cynomolgus Monkey FXN Protein (81-210 aa), His-tagged

Cat.No. : FXN-1060M
Product Overview : Recombinant Cynomolgus Monkey (Macaca fascicularis) (Crab-eating macaque) FXN Protein (81-210 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.
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Description : Promotes the biosynthesis of he and assbly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1.
Source : E. coli
Species : Cynomolgus Monkey
Tag : His
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 18.2 kDa
Protein length : 81-210 aa
AA Sequence : SGTLGHPGSLDDTTYERLAEETLDS LAEFFEDLADKPYTFEDYDVSFGSG VLTVKLGGDLGTYVINKQTPNKQIW LSSPSSGPKRYDRTGKNWVYSHDGV SLHELLGAELTKALKTKLDLSSLAY SGKDA
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
UniProt ID : Q8HXX9
UniProt ID : Q8HXX9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you elaborate on the interactions between FXN and iron regulatory proteins in the cell? 04/26/2022

FXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.

What is the impact of FXN deficiency on the sensitivity of cells to oxidative stress? 01/23/2021

FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.

Can you explain the chemistry behind the iron-sulfur cluster assembly facilitated by FXN? 08/28/2020

FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.

How does FXN contribute to the regulation of cellular energy metabolism? 02/09/2019

FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.

How does FXN deficiency lead to Friedreich's ataxia on a molecular level? 04/05/2018

FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.

Customer Reviews (3)

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Reviews
01/28/2021

    Customer service was courteous and efficient, guiding us through the product selection process with expertise.

    12/20/2019

      The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.

      09/02/2018

        Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.

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