Recombinant Cynomolgus NCR3 protein, His-tagged

• Cat.No.: NCR3-499C
• Product Overview: Recombinant Cynomolgus NCR3 (Asp25-Asp259) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Cynomolgus
• Source: HEK293
• Tag: His
• Protein Length: Asp25-Asp259
• Description: The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome.
  Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
• Predicted N Terminal: Asp25
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: NCR3
• Official Symbol: NCR3
• Synonyms: ncr; NKp30; NK-p30
• Gene ID: 102133932
• mRNA Refseq: XM_005553542.2
• Protein Refseq: XP_005553599.1
• UniProt ID: P61483