Recombinant Full Length Human ABCD1 Protein, C-Flag-tagged

• Cat.No.: ABCD1-320HFL
• Product Overview: Recombinant Full Length Human ABCD1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 82.8 kDa
• AA Sequence: MPVLSRPRPWRGNTLKRTAVLLALA AYGAHKVYPLVRQCLAPARGLQAPA GEPTQEASGVAAAKAGMNRV FLQRLLWLLRLLFPRVLCRETGLLA LHSAALVSRTFLSVYVARLDGRLAR CIVRKDPRAFGWQLLQWLLI ALPATFVNSAIRYLEGQLALSFRSR LVAHAYRLYFSQQTYYRVSNMDGRL RNPDQSLTEDVVAFAASVAH LYSNLTKPLLDVAVTSYTLLRAARS RGAGTAWPSAIAGLVVFLTANVLRA FSPKFGELVAEEARRKGELR YMHSRVVANSEEIAFYGGHEVELAL LQRSYQDLASQINLILLERLWYVML EQFLMKYVWSASGLLMVAVP IITATGYSESDAEAVKKAALEKKEE ELVSERTEAFTIARNLLTAAADAIE RIMSSYKEVTELAGYTARVH EMFQVFEDVQRCHFKRPRELEDAQA GSGTIGRSGVRVEGPLKIRGQVVDV EQGIICENIPIVTPSGEVVV ASLNIRVEEGMHLLITGPNGCGKSS LFRILGGLWPTYGGVLYKPPPQRMF YIPQRPYMSVGSLRDQVIYP DSVEDMQRKGYSEQDLEAILDVVHL HHILQREGGWEAMCDWKDVLSGGEK QRIGMARMFYHRPKYALLDE CTSAVSIDVEGKIFQAAKDAGIALL SITHRPSLWKYHTHLLQFDGEGGWK FEKLDSAARLSLTEEKQRLE
  QQLAGIPKMQRRLQELCQILGEAVA PAHVPAPSPQGPGGLQGASTTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: ABC transporters

Gene Information

• Gene Name: ABCD1 ATP binding cassette subfamily D member 1 [ Homo sapiens (human) ]
• Official Symbol: ABCD1
• Synonyms: ALD; AMN; ALDP; ABC42
• Gene ID: 215
• mRNA Refseq: NM_000033.4
• Protein Refseq: NP_000024.2
• MIM: 300371
• UniProt ID: P33897