Recombinant Full Length Human ITGB7 Protein, C-Flag-tagged

• Cat.No.: ITGB7-1417HFL
• Product Overview: Recombinant Full Length Human ITGB7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 86.7 kDa
• AA Sequence: MVALPMVLVLLLVLSRGESELDAKI PSTGDATEWRNPHLSMLGSCQPAPS CQKCILSHPSCAWCKQLNFT ASGEAEARRCARREELLARGCPLEE LEEPRGQQEVLQDQPLSQGARGEGA TQLAPQRVRVTLRPGEPQQL QVRFLRAEGYPVDLYYLMDLSYSMK DDLERVRQLGHALLVRLQEVTHSVR IGFGSFVDKTVLPFVSTVPS KLRHPCPTRLERCQSPFSFHHVLSL TGDAQAFEREVGRQSVSGNLDSPEG GFDAILQAALCQEQIGWRNV SRLLVFTSDDTFHTAGDGKLGGIFM PSDGHCHLDSNGLYSRSTEFDYPSV GQVAQALSAANIQPIFAVTS AALPVYQELSKLIPKSAVGELSEDS SNVVQLIMDAYNSLSSTVTLEHSSL PPGVHISYESQCEGPEKREG KAEDRGQCNHVRINQTVTFWVSLQA THCLPEPHLLRLRALGFSEELIVEL HTLCDCNCSDTQPQAPHCSD GQGHLQCGVCSCAPGRLGRLCECSV AELSSPDLESGCRAPNGTGPLCSGK GHCQCGRCSCSGQSSGHLCE CDDASCERHEGILCGGFGRCQCGVC HCHANRTGRACECSGDMDSCISPEG GLCSGHGRCKCNRCQCLDGY YGALCDQCPGCKTPCERHRDCAECG AFRTGPLATNCSTACAHTNVTLALA PILDDGWCKERTLDNQLFFF LVEDDARGTVVLRVRPQEKGADHTQ AIVLGCVGGIVAVGLGLVLAYRLSV EIYDRREYSRFEKEQQQLNW
  KQDSNPLYKSAITTTINPRFQEADS PTLSGPTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton

Gene Information

• Gene Name: ITGB7 integrin subunit beta 7 [ Homo sapiens (human) ]
• Official Symbol: ITGB7
• Synonyms: integrin, beta 7; integrin beta 7 subunit
• Gene ID: 3695
• mRNA Refseq: NM_000889.3
• Protein Refseq: NP_000880.1
• MIM: 147559
• UniProt ID: P26010