| Description : |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
177.4 kDa |
| AA Sequence : |
MPLAFCGSENHSAAYRVDQGVLNNG CFVDALNVVPHVFLLFITFPILFIG WGSQSSKVHIHHSTWLHFPGHNLRW ILTFMLLFVLVCEIAEGILSDGVTE SHHLHLYMPAGMAFMAAVTSVVYYH NIETSNFPKLLIALLVYWTLAFITK TIKFVKFLDHAIGFSQLRFCLTGLL VILYGMLLLVEVNVIRVRRYIFFKT PREVKPPEDLQDLGVRFLQPFVNLL SKGTYWWMNAFIKTAHKKPIDLRAI GKLPIAMRALTNYQRLCEAFDAQVR KDIQGTQGARAIWQALSHAFGRRLV LSSTFRILADLLGFAGPLCIFGIVD HLGKENDVFQPKTQFLGVYFVSSQE FLANAYVLAVLLFLALLLQRTFLQA SYYVAIETGINLRGAIQTKIYNKIM HLSTSNLSMGEMTAGQICNLVAIDT NQLMWFFFLCPNLWAMPVQIIVGVI LLYYILGVSALIGAAVIILLAPVQY FVATKLSQAQRSTLEYSNERLKQTN EMLRGIKLLKLYAWENIFRTRVETT RRKEMTSLRAFAIYTSISIFMNTAI PIAAVLITFVGHVSFFKEADFSPSV AFASLSLFHILVTPLFLLSSVVRST VKALVSVQKLSEFLSSAEIREEQCA PHEPTPQGPASKYQAVPLRVVNRKR PAREDCRGLTGPLQSLVPSADGDAD NCCVQIMGGYFTWTPDGIPTLSNIT IRIPRGQLTMIVGQVGCGKSSLLLA ALGEMQKVSGAVFWSSLPDSEIGED PSPERETATDLDIRKRGPVAYASQK PWLLNATVEENIIFESPFNKQRYKM VIEACSLQPDIDILPHGDQTQIGER GINLSGGQRQRISVARALYQHANVV FLDDPFSALDIHLSDHLMQAGILEL LRDDKRTVVLVTHKLQYLPHADWII AMKDGTIQREGTLKDFQRSECQLFE HWKTLMNRQDQELEKETVTERKATE PPQGLSRAMSSRDGLLQDEEEEEEE AAESEEDDNLSSMLHQRAEIPWRAC AKYLSSAGILLLSLLVFSQLLKHMV LVAIDYWLAKWTDSALTLTPAARNC SLSQECTLDQTVYAMVFTVLCSLGI VLCLVTSVTVEWTGLKVAKRLHRSL LNRIILAPMRFFETTPLGSILNRFS SDCNTIDQHIPSTLECLSRSTLLCV SALAVISYVTPVFLVALLPLAIVCY FIQKYFRVASRDLQQLDDTTQLPLL SHFAETVEGLTTIRAFRYEARFQQK LLEYTDSNNIASLFLTAANRWLEVR MEYIGACVVLIAAVTSISNSLHREL SAGLVGLGLTYALMVSNYLNWMVRN LADMELQLGAVKRIHGLLKTEAESY EGLLAPSLIPKNWPDQGKIQIQNLS VRYDSSLKPVLKHVNALIAPGQKIG ICGRTGSGKSSFSLAFFRMVDTFEG HIIIDGIDIAKLPLHTLRSRLSIIL QDPVLFSGTIRFNLDPERKCSDSTL WEALEIAQLKLVVKALPGGLDAIIT EGGENFSQGQRQLFCLARAFVRKTS IFIMDEATASIDMATENILQKVVMT AFADRTVVTIAHRVHTILSADLVIV LKRGAILEFDKPEKLLSRKDSVFAS FVRADKTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
