Recombinant Human ABI1 Protein, Myc/DDK-tagged, C13 and N15-labeled ABI1-4188H

Recombinant Human ABI1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human ABI1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : ABI1-4188H
Product Overview : ABI1 MS Standard C13 and N15-labeled recombinant protein (NP_005461) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 55.1 kDa
AA Sequence : MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE NSGSSSIGIP IAVPTPSPPT IGPAPGSAPG SQYGTMTRQI SRHNSTTSST SSGGYRRTPS VTAQFSAQPH VNGGPLYSQN SIADSPTPPP PPPPDDIPMF DDSPPPPPPP PVDYEDEEAA VVQYNDPYAD GDPAWAPKNY IEKVVAIYDY TKDKDDELSF MEGAIIYVIK KNDDGWYEGV CNRVTGLFPG NYVESIMHYT DTRTRPLEQK LISEEDLAAN DILDYKDDDD KV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : ABI1 abl-interactor 1 [ Homo sapiens (human) ]
Official Symbol : ABI1
Synonyms : ABI1; abl-interactor 1; spectrin SH3 domain binding protein 1, SSH3BP1; abl interactor 1; ABI 1; E3B1; Abelson interactor 1; nap1 binding protein; abl-binding protein 4; interactor protein AblBP4; Abl-interactor protein 1 long; eps8 SH3 domain-binding protein; spectrin SH3 domain-binding protein 1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1;
Gene ID : 10006
mRNA Refseq : NM_005470
Protein Refseq : NP_005461
MIM : 603050
UniProt ID : Q8IZP0
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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