Recombinant Human Aminopeptidase N(ANPEP) ,partial

• Cat.No.: ANPEP-250H
• Product Overview: Recombinant Human ANPEP extracellular domain(858-967aa), fussed with His-sumo-tag at C-terminal, was expressed in E. coli.

Specification

• Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
• Source: E. coli
• Species: Human
• Tag: His-sumo
• Form: Tris-based buffer,50% glycerol
• Protein length: 858-967aa
• Purity: >90%
• Stability: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.
• Shipping: 30-40 work days

Gene Information

• Gene Name: ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens ]
• Official Symbol: ANPEP
• Synonyms: APN; CD13; LAP1; P150; PEPN; GP150; aminopeptidase N; AP-M; AP-N; alanyl aminopeptidase; aminopeptidase M; hAPN; microsomal aminopeptidase; myeloid plasma membrane glycoprotein CD13
• Gene ID: 290
• mRNA Refseq: NM_001150
• Protein Refseq: NP_001141
• MIM: 151530
• UniProt ID: P15144
• Chromosome Location: 15q25-q26
• Pathway: C-MYB transcription factor network, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: aminopeptidase activity; metallopeptidase activity; receptor activity