Recombinant Human CADPS Protein, GST-Tagged

• Cat.No.: CADPS-0283H
• Product Overview: Human CADPS full-length ORF (AAH15754.1, 1 a.a. - 222 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 52.1 kDa
• AA Sequence: MFNVMVDAKAQSTKLCSMEMGQEFA KMWHQYHSKIDELIEETVKEMITLL VAKFVTILEGVLAKLSRYDEGTLFS SFLSFTVKAASKYVDVPKPGMDVAD AYVTFVRHSQDVLRDKVNEEMYIER LFDQWYNSSMNVICTWLTDRMDLQL HIYQLKTLIRMVKKTYRDFRLQGVL DSTLNSKTYETIRNRLTVEEATASV SEGGGLQGISMKDSDEEDEEDD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CADPS Ca++-dependent secretion activator [ Homo sapiens ]
• Official Symbol: CADPS
• Synonyms: CAPS; CAPS1; CADPS1
• Gene ID: 8618
• mRNA Refseq: NM_183394
• Protein Refseq: NP_899631
• MIM: 604667
• UniProt ID: Q9ULU8

Reviews

03/15/2021

The product's proteins save us time.

09/26/2020

Our data's accuracy is thanks to these products.

05/06/2018

These proteins are indispensable for scientific advancements.

Q&As

Can you describe the molecular mechanism by which CADPS regulates vesicle priming?

CADPS interacts with Munc13 and facilitates the transition of synaptic vesicles from a "docked" to a "primed" state, making them ready for fusion upon calcium influx.

How does CADPS contribute to the regulation of neurotransmitter release at the molecular level?

CADPS promotes the docking and priming of synaptic vesicles at the presynaptic membrane, ensuring efficient neurotransmitter release upon calcium influx.

Can you explain the interaction between CADPS and SNARE proteins?

CADPS interacts with SNARE proteins such as Syntaxin and SNAP-25, facilitating the assembly of the SNARE complex, which is crucial for vesicle fusion.

How is CADPS protein structured at the molecular level?

CADPS consists of multiple domains, including a C2 domain that binds calcium ions and a Munc13 homology domain (MHD) that interacts with SNARE proteins and helps in vesicle priming.

Are there any other proteins that directly interact with CADPS in the molecular context?

Yes, proteins like RIM (Rab3-interacting molecule) and Liprin-α have been shown to interact with CADPS and play a role in synaptic vesicle trafficking.