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Active Recombinant Human CASP3 Protein, His-tagged

Cat.No. : CASP3-01H
Product Overview : Human caspase 3 (CASP3), also known as CPP32 and apopain, a.a. 1 – 277 (end) with C-terminal His-tag, expressed in an E. coli expression system.
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  • Gene Information
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Description : The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Source : E. coli
Species : Human
Tag : His
Form : Aqueous buffer solution
Bio-activity : ≥ 6,784 pmol/min/µg
Molecular Mass : 17 kDa and 13 kDa
Protein length : 1-277
AA Sequence : MENTENSVDSKSIKNLEPKIIHGSE SMDSGISLDNSYKMDYPEMGLCIII NNKNFHKSTGMTSRSGTDVDAANLR ETFRNLKYEVRNKNDLTREEIVELM RDVSKEDHSKRSSFVCVLLSHGEEG IIFGTNGPVDLKKITNFFRGDRCRS LTGKPKLFIIQACRGTELDCGIETD SGVDDDMACHKIPVEADFLYAYSTA PGYYSWRNSKDGSWFIQSLCAMLKQ YADKLEFMHILTRVNRKVATEFESF SFDATFHAKKQIPCIVSMLTKELYF YHHHHHHH
Purity : > 99%
Applications : Enzyme kinetics, screening inhibitors, and selectivity profiling
Stability : > 6 months
Storage : Store at -80 centigrade
Storage Buffer : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol and 3 mM DTT
Gene Name : CASP3 caspase 3 [ Homo sapiens (human) ]
Official Symbol : CASP3
Synonyms : CASP3; caspase 3; CPP32; SCA-1; CPP32B; caspase-3; CASP-3; CPP-32; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32; procaspase3; protein Yama
Gene ID : 836
mRNA Refseq : NM_004346
Protein Refseq : NP_004337
MIM : 600636
UniProt ID : P42574

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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