Recombinant Human CASP3 Protein, His-tagged CASP3-01H

Recombinant Human CASP3 Protein, His-tagged

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Recombinant Human CASP3 Protein, His-tagged

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Cat.No. : CASP3-01H
Product Overview : Human caspase 3 (CASP3), also known as CPP32 and apopain, a.a. 1 – 277 (end) with C-terminal His-tag, expressed in an E. coli expression system.
Description : The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Source : E. coli
Species : Human
Tag : His
Form : Aqueous buffer solution
Bio-activity : ≥ 6,784 pmol/min/µg
Molecular Mass : 17 kDa and 13 kDa
Protein length : 1-277
AA Sequence : MENTENSVDSKSIKN LEPKIIHGSESMDSG ISLDNSYKMDYPEMG LCIIINNKNFHKSTG MTSRSGTDVDAANLR ETFRNLKYEVRNKND LTREEIVELMRDVSK EDHSKRSSFVCVLLS HGEEGIIFGTNGPVD LKKITNFFRGDRCRS LTGKPKLFIIQACRG TELDCGIETDSGVDD DMACHKIPVEADFLY AYSTAPGYYSWRNSK DGSWFIQSLCAMLKQ YADKLEFMHILTRVN RKVATEFESFSFDAT FHAKKQIPCIVSMLT KELYFYHHHHHHH
Purity : > 99%
Applications : Enzyme kinetics, screening inhibitors, and selectivity profiling
Stability : > 6 months
Storage : Store at -80 centigrade
Storage Buffer : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol and 3 mM DTT
Caspase 3 activity :

SDS-PAGE of CASP3 :

Lane 1: 2 µg Caspase 3; Lane 2: Protein Markers

Gene Name : CASP3 caspase 3 [ Homo sapiens (human) ]
Official Symbol : CASP3
Synonyms : CASP3; caspase 3; CPP32; SCA-1; CPP32B; caspase-3; CASP-3; CPP-32; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32; procaspase3; protein Yama
Gene ID : 836
mRNA Refseq : NM_004346
Protein Refseq : NP_004337
MIM : 600636
UniProt ID : P42574

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