Recombinant Human CASTOR1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | CASTOR1-3060H |
Product Overview : | GATSL3 MS Standard C13 and N15-labeled recombinant protein (NP_001032755) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 36.3 kDa |
AA Sequence : | MELHILEHRVRVLSVARPGLWLYTH PLIKLLFLPRRSRCKFFSLTETPED YTLMVDEEGFKELPPSEFLQVAEAT WLVLNVSSHSGAAVQAAGVTKIARS VIAPLAEHHVSVLMLSTYQTDFILV REQDLSVVIHTLAQEFDIYREVGGE PVPVTRDDSSNGFPRTQHGPSPTVH PIQSPQNRFCVLTLDPETLPAIATT LIDVLFYSHSTPKEAASSSPEPSSI TFFAFSLIEGYISIVMDAETQKKFP SDLLLTSSSGELWRMVRIGGQPLGF DECGIVAQIAGPLAAADISAYYIST FNFDHALVPEDGIGSVIEVLQRRQE GLASTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 [ Homo sapiens (human) ] |
Official Symbol : | CASTOR1 |
Synonyms : | CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1; GATSL3; cytosolic arginine sensor for mTORC1 subunit 1; GATS protein like 3; GATS-like protein 3; cellular arginine sensor for mTORC1 protein 1 |
Gene ID : | 652968 |
mRNA Refseq : | NM_001037666 |
Protein Refseq : | NP_001032755 |
MIM : | 617034 |
UniProt ID : | Q8WTX7 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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