| Description : |
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
40.3 kDa |
| AA Sequence : |
MRWFLPWTLAAVTAAAASTVLATAL SPAPTTMDFTPAPLEDTSSRPQFCK WPCECPPSPPRCPLGVSLITDGCEC CKMCAQQLGDNCTEAAICDPHRGLY CDYSGDRPRYAIGVCAQVVGVGCVL DGVRYNNGQSFQPNCKYNCTCIDGA VGCTPLCLRVRPPRLWCPHPRRVSI PGHCCEQWVCEDDAKRPRKTAPRDT GAFDAVGEVEAWHRNCIAYTSPWSP CSTSCGLGVSTRISNVNAQCWPEQE SRLCNLRPCDVDIHTLIKAGKKCLA VYQPEASMNFTLAGCISTRSYQPKY CGVCMDNRCCIPYKSKTIDVSFQCP DGLGFSRQVLWINACFCNLSCRNPN DIFADLESYPDFSEIANTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
