Recombinant Human CD207 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CD207-3416H
• Product Overview: CD207 MS Standard C13 and N15-labeled recombinant protein (NP_056532) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.7 kDa
• AA Sequence: MTVEKEAPDAHFTVDKQNISLWPRE PPPKSGPSLVPGKTPTVRAALICLT LVLVASVLLQAVLYPRFMGTISDVK TNVQLLKGRVDNISTLDSEIKKNSD GMEAAGVQIQMVNESLGYVRSQFLK LKTSVEKANAQIQILTRSWEEVSTL NAQIPELKSDLEKASALNTKIRALQ GSLENMSKLLKRQNDILQVVSQGWK YFKGNFYYFSLIPKTWYSAEQFCVS RNSHLTSVTSESEQEFLYKTAGGLI YWIGLTKAGMEGDWSWVDDTPFNKV QSARFWIPGEPNNAGNNEHCGNIKA PSLQAWNDAPCDKTFLFICKRPYVP SEPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CD207 CD207 molecule [ Homo sapiens (human) ]
• Official Symbol: CD207
• Synonyms: CD207; CD207 molecule, langerin; CD207 antigen, langerin; C-type lectin domain family 4 member K; CLEC4K; Langerin; Langerhans cell specific c-type lectin; C-type lectin domain family 4, member K
• Gene ID: 50489
• mRNA Refseq: NM_015717
• Protein Refseq: NP_056532
• MIM: 604862
• UniProt ID: Q9UJ71