Recombinant Human CD274 Protein
Cat.No. : | CD274-593H |
Product Overview : | Recombinant Human CD274 Protein (NP_054862.1, Met1-Arg238) was expressed in HEK293 cells. |
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Description : | Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. |
Source : | HEK293 |
Species : | Human |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Molecular Mass : | The recombinant human CD274 consists of 220 amino acids and predicts a molecular mass of 25.2 kDa. |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Reconstitute in ddH2O. |
Gene Name : | CD274 CD274 molecule [ Homo sapiens ] |
Official Symbol : | CD274 |
Synonyms : | CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; |
Gene ID : | 29126 |
mRNA Refseq : | NM_014143 |
Protein Refseq : | NP_054862 |
MIM : | 605402 |
UniProt ID : | Q9NZQ7 |
Products Types
◆ Recombinant Protein | ||
CD274-199C | Recombinant Human CD274 Protein, His-tagged | +Inquiry |
CD274-6778H | Recombinant Human CD274 Protein, His&T7-tagged | +Inquiry |
CD274-558R | Recombinant Rhesus Macaque CD274 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD274-051H | Active Recombinant Human CD274 protein(Met1-Thr239), His&Avi-tagged, Biotinylated | +Inquiry |
CD274-0765H | Recombinant Human CD274 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CD274-2735HCL | Recombinant Human CD274 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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