Recombinant Human CD276 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CD276-586H
• Product Overview: CD276 MS Standard C13 and N15-labeled recombinant protein (NP_079516) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 33.6 kDa
• AA Sequence: MLRRRGSPGMGVHVGAALGALWFCL TGALEVQVPEDPVVALVGTDATLCC SFSPEPGFSLAQLNLIWQLTDTKQL VHSFAEGQDQGSAYANRTALFPDLL AQGNASLRLQRVRVADEGSFTCFVS IRDFGSAAVSLQVAAPYSKPSMTLE PNKDLRPGDTVTITCSSYRGYPEAE VFWQDGQGVPLTGNVTTSQMANEQG LFDVHSVLRVVLGANGTYSCLVRNP VLQQDAHGSVTITGQPMTFPPEALW VTVGLSVCLIALLVALAFVCWRKIK QSCEEENAGAEDQDGEGEGSKTALQ PLKHSDSKEDDGQEIATRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CD276 CD276 molecule [ Homo sapiens (human) ]
• Official Symbol: CD276
• Synonyms: CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3
• Gene ID: 80381
• mRNA Refseq: NM_025240
• Protein Refseq: NP_079516
• MIM: 605715
• UniProt ID: Q5ZPR3