Recombinant Human CD86, Fc-His tagged

• Cat.No.: CD86-55H
• Product Overview: Recombinant Human CD86 extracellular domain (Met 1-His 239) (NP_008820.2), fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus, was produced in Human Cell.

Specification

• Source: Human Cells
• Species: Human
• Tag: His&Fc
• Form: Lyophilized from sterile PBS, pH 7.4
• Molecular Mass: The recombinant human B7-2/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 467 amino acids and has a predicted molecular mass of 53.2 kDa. In SDS-PAGE, the apparent molecular mass of rh B7-2/Fc monomer is approximately 80-90 kDa due to glycosylation.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Protein length: Met1-His239

Gene Information

• Gene Name: CD86 CD86 molecule [ Homo sapiens ]
• Official Symbol: CD86
• Gene ID: 942
• mRNA Refseq: NM_001206924
• Protein Refseq: NP_001193853
• MIM: 601020
• UniProt ID: P42081

Reviews

01/09/2022

With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

05/30/2021

Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

12/08/2017

The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

Q&As

Are there any ongoing clinical trials involving CD86 inhibitors?

Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.

How does CD86 contribute to transplant medicine?

In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.

How does CD86 influence the balance between Th1 and Th2 immune responses?

CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.

Can CD86 be used as a prognostic marker in certain diseases?

There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.

How does CD86 influence the development of regulatory T cells (Tregs)?

CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.