Recombinant Human CDK2AP1 Protein, GST-Tagged

• Cat.No.: CDK2AP1-1005H
• Product Overview: Human CDK2AP1 full-length ORF (AAH34717, 1 a.a. - 115 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 38.39 kDa
• AA Sequence: MSYKPNLAAHMPAAALNAAGSVHSP STSMATSSQYRQLLSDYGPPSLGYT QGTGNSQVPQSKYAELLAIIEELGK EIRPTYAGSKSAMERLKRGIIHARG LVRECLAETERNARS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CDK2AP1 cyclin-dependent kinase 2 associated protein 1 [ Homo sapiens ]
• Official Symbol: CDK2AP1
• Synonyms: CDK2AP1; cyclin-dependent kinase 2 associated protein 1; CDK2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; doc 1; DOC1; DORC1; p12DOC 1; ST19; Deleted in oral cancer-1; deleted in oral cancer 1; CDK2-associated protein 1; putative oral cancer suppressor; doc-1; p12DOC-1
• Gene ID: 8099
• mRNA Refseq: NM_004642
• Protein Refseq: NP_004633
• MIM: 602198
• UniProt ID: O14519