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Recombinant Human CLC Protein, His-tagged

Cat.No. : CLC-616H
Product Overview : Recombinant Human CLC(Ser2~Arg142) fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 17.8kDa
Protein length : Ser2~Arg142
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : CLC Charcot-Leyden crystal protein [ Homo sapiens ]
Official Symbol : CLC
Synonyms : CLC; Charcot-Leyden crystal protein; eosinophil lysophospholipase; galectin 10; LGALS10; LPPL_HUMAN; lysolecithin acylhydrolase; MGC149659; galectin-10; GAL10; Gal-10; LGALS10A;
Gene ID : 1178
mRNA Refseq : NM_001828
Protein Refseq : NP_001819
MIM : 153310
UniProt ID : Q05315

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CLC proteins be targeted for the treatment of neurological disorders? 01/28/2022

There is emerging evidence that CLC proteins may play a role in neurological disorders, making them potential targets for drug development in this field.

How are CLC proteins involved in renal function and disorders? 12/01/2020

CLC proteins are involved in the transport of chloride ions in the kidney, and mutations in CLC genes can lead to renal disorders such as Bartter syndrome.

Can targeting CLC proteins be beneficial for the treatment of renal disorders? 07/17/2019

Modulating the activity of CLC proteins may offer potential therapeutic benefits in the treatment of certain renal disorders by restoring normal chloride ion transport.

Can CLC proteins be targeted for the development of novel pain medications? 01/05/2018

There is evidence suggesting that CLC proteins may play a role in pain perception, making them potential targets for the development of novel pain medications.

Are there any clinical trials targeting CLC proteins for therapeutic intervention? 12/25/2017

Several research groups are investigating the potential of targeting CLC proteins for therapeutic intervention in muscle disorders and cystic fibrosis.

Customer Reviews (3)

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Reviews
07/12/2019

    the high-quality CLC protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

    06/05/2018

      This enables researchers to confidently incorporate CLC into their studies, knowing that they have access to a reliable and well-characterized protein that will contribute to robust and accurate results.

      10/02/2016

        The knowledgeable and responsive support team is dedicated to resolving issues and providing solutions that are tailored to specific experimental requirements.

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