Recombinant Human CSF2 therapeutic protein(Sargramostim)
Cat.No. : | CSF2-P035H |
Product Overview : | Recombinant Human Colony Stimulating Factor 2 is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein. |
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Description : | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The expression product is the active ingredient of Immunex, Leucomax and Leukine. |
Source : | Yeast |
Species : | Human |
Molecular Mass : | 14.4 kDa |
Protein length : | 127 aa |
AA Sequence : | APARSPSPSTQPWEHVNAIQEALRL LNLSRDTAAEMNETVEVISEMFDLQ EPTCLQTRLELYKQGLRGSLT KLKGPLTMMASHYKQHCPPTPETSC ATQIITFESFKENLKDFLLVIPFDC WEPVQE |
Endotoxin : | < 1.0 EU per μg of the protein |
Purity : | >95% |
Storage : | Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles. |
Tag : | Non |
Alias : | CSF2; GM CSF; GMCSF; Sargramostim |
Gene Name : | CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ] |
Official Symbol : | CSF2 |
Synonyms : | CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; |
Gene ID : | 1437 |
mRNA Refseq : | NM_000758 |
Protein Refseq : | NP_000749 |
MIM : | 138960 |
UniProt ID : | P04141 |
Chromosome Location : | 5q23-q31 |
Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding; |
Products Types
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CSF2-17H | Active Recombinant Human CSF2 Protein, Animal Free | +Inquiry |
◆ Lysates | ||
CSF2-740RCL | Recombinant Rat CSF2 cell lysate | +Inquiry |
CSF2-3008HCL | Recombinant Human CSF2 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.
The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.
Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.
Q&As (7)
Ask a questionThe sequence of CSF2 is moderately conserved across different species.
The length of CSF2 protein varies but is typically around 144 amino acids.
The primary function of CSF2 is to regulate the production and differentiation of white blood cells.
CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.
CSF2 stands for Colony Stimulating Factor 2.
CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.
CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.
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