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Recombinant Human CSF2 therapeutic protein(Sargramostim)

Cat.No. : CSF2-P035H
Product Overview : Recombinant Human Colony Stimulating Factor 2 is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
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Description : The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The expression product is the active ingredient of Immunex, Leucomax and Leukine.
Source : Yeast
Species : Human
Molecular Mass : 14.4 kDa
Protein length : 127 aa
AA Sequence : APARSPSPSTQPWEHVNAIQEALRL LNLSRDTAAEMNETVEVISEMFDLQ EPTCLQTRLELYKQGLRGSLT KLKGPLTMMASHYKQHCPPTPETSC ATQIITFESFKENLKDFLLVIPFDC WEPVQE
Endotoxin : < 1.0 EU per μg of the protein
Purity : >95%
Storage : Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Tag : Non
Alias : CSF2; GM CSF; GMCSF; Sargramostim
Gene Name : CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ]
Official Symbol : CSF2
Synonyms : CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897;
Gene ID : 1437
mRNA Refseq : NM_000758
Protein Refseq : NP_000749
MIM : 138960
UniProt ID : P04141
Chromosome Location : 5q23-q31
Pathway : Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding;

Not For Human Consumption!

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Customer Reviews (3)

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01/15/2022

    The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

    07/27/2021

      The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

      05/19/2019

        Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

        Q&As (7)

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        How conserved is the sequence of CSF2 among different species? 05/15/2021

        The sequence of CSF2 is moderately conserved across different species.

        What is the typical length of CSF2? 01/30/2021

        The length of CSF2 protein varies but is typically around 144 amino acids.

        What is the main biological function of CSF2? 05/01/2019

        The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

        In what tissues or cells is CSF2 commonly expressed? 02/03/2019

        CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

        What does CSF2 stand for? 07/10/2018

        CSF2 stands for Colony Stimulating Factor 2.

        Is CSF2 associated with any specific diseases or conditions? 03/17/2018

        CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

        Which cellular functions are associated with CSF2? 02/20/2017

        CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.

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